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Home » Dinner » Mexican Casserole

Published: May 5, 2022 Last Modified: May 5, 2022 By Sara 23 Comments

Mexican Casserole

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This Mexican casserole is made with ground beef, tortillas, vegetables and cheese, all layered together and baked to golden brown perfection.
This Mexican casserole is made with ground beef, tortillas, vegetables and cheese, all layered together and baked to golden brown perfection.
This Mexican casserole is made with ground beef, tortillas, vegetables and cheese, all layered together and baked to golden brown perfection.

This Mexican casserole is made with ground beef, tortillas, vegetables and cheese, all layered together and baked to golden brown perfection. A quick and easy dinner for busy weeknights!

My family adores all Mexican inspired food, including Chipotle chicken, vegetarian fajitas, and this hearty Mexican casserole.

A plate of Mexican casserole with layers of meat, tortillas and cheese.

You can never go wrong with a casserole, especially when it’s loaded with plenty of meat, tortillas and cheese! This Mexican casserole is a huge hit with both kids and adults, and is great for feeding a crowd.

Mexican Casserole Ingredients

Ingredients including ground beef, tortillas, vegetables and seasonings.

This casserole consists of easy to locate ingredients including ground beef, tortillas, taco seasoning, vegetables, cheese and enchilada sauce.

How do you make Mexican casserole?

Start by cooking the ground beef in a pan. Add the onions, then stir in taco seasoning. Next, add tomatoes and corn to the beef mixture. Layer tortillas, the beef mixture, shredded cheese and enchilada sauce into a baking dish. Repeat the layers, then sprinkle extra cheese over the final layer. Bake until the casserole is bubbly and the cheese is melted. Add any toppings of your choice, then serve.

Process shots showing beef and vegetables being cooked and casserole assembly.

Tips for the perfect dish

  • To make this casserole in advance, assemble all the layers, then cover the casserole dish with foil and refrigerate for up to one day. When it’s time to eat, follow the baking instructions in the recipe, but add 15 minutes more to the bake time to compensate for starting with a cold casserole.
  • You can serve your casserole as-is, or add some toppings such as cilantro, lettuce, sour cream, avocado or sliced olives. For an extra special touch, whip up a homemade topping such as Chipotle guacamole, salsa fresca, or corn salsa.
  • Need a side dish to serve with your casserole? Try my easy cilantro lime rice.
  • I recommend using 90% lean ground beef. It has plenty of flavor without a lot of grease. If you use beef with a higher fat content, you may need to drain off any excess grease after it’s cooked.
  • This recipe works best with freshly grated cheese. The bags of shredded cheese at the grocery store are often coated with preservatives and anti caking agents and do not melt well.
Layers of meat, cheese and sauce going into a casserole dish.

Recipe FAQs

What do you put in a Mexican casserole?

Most Mexican casseroles contain meat, chips or tortillas, and cheese. They also often contain a sauce, such as salsa or enchilada sauce. A Mexican casserole is often topped with melted cheese, and fresh garnishes such as pico de gallo or avocado.

How long do you bake a Mexican casserole?

A Mexican casserole should bake for about 35-40 minutes. I start by baking the casserole covered, then uncover it during the last few minutes. This allows for all the flavors to meld together yet keeps the top of the casserole from burning.

A baking dish filled with Mexican casserole, topped with fresh salsa.

Flavor variations

Sometimes I make this casserole with different ingredients, depending on what I have on hand. You can easily customize this recipe to your family’s tastes!

  • Protein: Swap out the ground beef for ground turkey, or use cooked shredded chicken instead. You can also turn this into a vegetarian dish by using a can of black beans and a can of pinto beans.
  • Tortillas: While I typically make this recipe with corn tortillas, flour tortillas will also work just fine.
  • Cheese: No cheddar on hand? Try using Monterey Jack, colby or pepper jack instead.
  • Vegetables: Feel free to add other veggies to the filling such as cooked zucchini, roasted green chilies, mushrooms or bell peppers.
  • Flavorings: Stir in some favorites such as olives, or add hot sauce for a spicy kick. You can also use green enchilada sauce instead of red.

Once you see how easy and delicious this Mexican casserole is, you’ll find yourself making it on a regular basis!

More casserole recipes you’ll love

  • Hashbrown Casserole
  • Chicken and Rice Casserole
  • Chile Relleno Casserole
  • Mexican Casserole
  • Beef Noodle Casserole
A plate of Mexican casserole with layers of meat, tortillas and cheese.
Print Pin
5 from 15 votes

Mexican Casserole

This Mexican casserole is made with ground beef, tortillas, vegetables and cheese, all layered together and baked to golden brown perfection. A quick and easy dinner for busy weeknights!
Course Main
Cuisine Mexican
Prep Time 20 minutes
Cook Time 45 minutes
Total Time 1 hour 5 minutes
Servings 6
Calories 435kcal
Author Sara Welch

Ingredients

  • 2 teaspoons vegetable oil
  • 1 pound ground beef
  • 1/2 cup onion finely diced
  • 1 packet taco seasoning
  • 15 ounce can diced tomatoes drained
  • 3/4 cup frozen corn kernels thawed
  • 2 cups red enchilada sauce
  • 8 6-inch tortillas halved
  • 2 cups shredded cheddar cheese
  • cooking spray
  • salsa, sour cream, cilantro, avocado optional, for garnish

Instructions

  • Preheat the oven to 350 degrees F. Coat a 2 or 3 quart casserole dish with cooking spray.
  • Heat the oil in a pan over medium heat. Add the ground beef and crumble with a spoon. Cook until browned, 6-7 minutes.
  • Add the onion and cook for an additional 4-5 minutes or until softened.
  • Stir in the taco seasoning and 2 tablespoons of water.
  • Add the tomatoes and corn and stir to combine.
  • Spread 1/4 cup of enchilada sauce over the bottom of the baking dish. Layer 4 halves of tortilla over the sauce so that the bottom of the pan is covered.
  • Layer 1/3 of the beef mixture, 1/2 cup of the cheese and 1/3 cup of enchilada sauce over the tortillas.
  • Place a second layer of tortillas on top and layer 1/3 of the beef, 1/2 cup of the cheese and 1/3 cup enchilada sauce over the tortillas.
  • Repeat this process one more time for the third layer. Place the remaining tortilla halves over the top and spread the remaining enchilada sauce over the tortillas.
  • Sprinkle the remaining 1/2 cup cheese over the top.
  • Cover with foil that's been sprayed with cooking spray and bake for 30 minutes. Uncover and bake for an additional 5-10 minutes or until cheese is melted and browned.
  • Let sit for 5 minutes to firm up, then top with garnishes if desired and serve.

Notes

  1. To make this casserole in advance, assemble all the layers, then cover the casserole dish with foil and refrigerate for up to one day. When it’s time to eat, follow the baking instructions in the recipe, but add an extra 15 minutes to the bake time to compensate for starting with a cold casserole.
  2. I recommend using 90% lean ground beef. It has plenty of flavor without a lot of grease. If you use beef with a higher fat content, you may need to drain off any excess grease after it’s cooked.
  3. This recipe works best with freshly grated cheese. The bags of shredded cheese at the grocery store are often coated with preservatives and anti caking agents and do not melt well.

Nutrition

Calories: 435kcal | Carbohydrates: 35g | Protein: 29g | Fat: 21g | Saturated Fat: 12g | Cholesterol: 106mg | Sodium: 596mg | Potassium: 428mg | Fiber: 2g | Sugar: 5g | Vitamin A: 940IU | Vitamin C: 7.4mg | Calcium: 327mg | Iron: 2.6mg
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    Comments

    1. Ana Moreno says

      August 1, 2022 at 9:21 am

      Could you substitute the ground beef and taco seasoning with chorizo?

      Reply
      • Sara says

        August 1, 2022 at 10:55 am

        I think that should work although I haven’t tested it myself!

        Reply
        • Ana Moreno says

          August 8, 2022 at 8:44 am

          I made this recipe this weekend with the chorizo. It was delicious. However, the kids thought it was spicy so I probably will not make it again with the chorizo when I’m making it for them.

          Reply
    2. Beth says

      June 1, 2022 at 5:09 pm

      Flour or corn tortillas? This looks amazing!!

      Reply
      • Sara says

        June 2, 2022 at 9:46 am

        Either will work but I typically use corn!

        Reply
    3. Vidya Narayan says

      May 10, 2022 at 1:35 am

      5 stars
      Looks absolutely amazing. A great weeknight dinner recipe especially for all the Mexican food lovers.

      Reply
    4. Amanda Wren-Grimwood says

      May 10, 2022 at 12:42 am

      5 stars
      I’ve been looking for more ground beef recipes as we’ve got into a bit of a rut. This recipe is perfect and so easy to do!

      Reply
    5. Ieva says

      May 9, 2022 at 11:23 pm

      5 stars
      Absolutely delicious! It’s almost like a Mexican lasagna! We made it with ground turkey and it was really very good! Loved the spices! Will make it again soon, as it received rave reviews at our dinner table! 🙂

      Reply
    6. Sharon says

      May 9, 2022 at 10:41 pm

      5 stars
      This was delicious and I was happy to have all of the ingredients already on hand! Super easy-to-follow recipe. Thanks!

      Reply
    7. Anjali says

      May 9, 2022 at 10:29 pm

      5 stars
      This casserole was so spicy, hearty and filling! It was the perfect dinner for our family tonight – super kid friendly too!

      Reply
    8. Rodd says

      December 27, 2019 at 1:04 pm

      love the concept of this recipe.Used leftover chalupa in place of the chicken and beans,turned out yummy.

      Reply
    9. Deb says

      December 9, 2019 at 8:26 pm

      5 stars
      This is one of my favorite casseroles! So yummy and cheesy! I’ve frozen it and it was still good!

      Reply
    10. Nikki Krakauer aka “JustTabandMe” says

      April 11, 2019 at 1:51 pm

      5 stars
      I suspect your family enjoys Mexican food just as much as I and my grown children do! I have tried your Chicken Enchilada casserole VERY much, and found this recipe to be almost the same. However, I admit, I prefer the chicken Enchiladas best! Not exactly sure why though! But best thing is, I have *lots* of frozen Mexican meals in my freezer! AND, one of them, 1/2 serving size, got paired with my already frozen 1/2 portion of the other! It’s next in line for next weeks meal rotation!! I may need to amend my review of this one! Thanks for posting this! Blessings!!!

      Reply
    11. StylishGeek says

      January 29, 2019 at 3:53 pm

      5 stars
      This Mexican casserole is a fantastic recipe! It has all the ingredients that I want! I have to make it! Thanks for sharing your post!

      Reply
    12. Autumn Murray says

      January 29, 2019 at 11:40 am

      5 stars
      This Mexican Casserole recipe looks like a delicious change up in my weekly menu plan. Thank you!

      Reply
    13. Becca Wilson says

      January 29, 2019 at 11:07 am

      Casseroles are so very easy and I love how delicious the combos can be. I have never made a mexican casserole before but my family would love this!

      Reply
    14. Bryan says

      January 29, 2019 at 9:27 am

      5 stars
      This looks delicious! I feel like there’s a lot of flavor in this casserole. I think I’ll add jalapenos to this recipe too, thank you. Great recipe!

      Reply
    15. Kiwi says

      January 29, 2019 at 12:16 am

      I love Mexican food and I would love to recreate this. I would have to make this vegetarian style no chicken.

      Reply
    16. Marcie W. says

      January 28, 2019 at 3:08 pm

      5 stars
      Wow, this casserole looks super delicious. Love all of the veggies involved too!

      Reply
    17. Sharon Wu says

      January 28, 2019 at 3:06 pm

      ahhh i think i know what i’m making for dinner tonight. this looks absolutely scrumptious and i know my bf would love it too. thank you for sharing! xx

      Reply
    18. Amy says

      January 28, 2019 at 1:39 pm

      5 stars
      Wow, this looks so scrumptious!! I totally need some of this in my life. Cheese is everything!

      Reply
    19. Brianne Tursi Manz says

      January 28, 2019 at 11:52 am

      5 stars
      I’m all about that cheese! This is an awesome dish, that I know my family would absolutely love!

      Reply
    20. Stacie says

      January 28, 2019 at 11:36 am

      5 stars
      That looks fantastic! I love that cheesy goodness on the top. My family would love this.

      Reply

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