A serving of Mexican casserole made with flour tortillas, cheese, chicken and vegetables.

Mexican Casserole

This Mexican casserole is made with chicken, vegetables, tortillas and cheese, all in a zesty creamy sauce. An easy dinner to feed a crowd, and it takes just minutes to put together!
Course Main
Cuisine Mexican
Keyword mexican casserole, mexican chicken casserole
Prep Time 20 minutes
Cook Time 35 minutes
Total Time 55 minutes
Servings 6
Calories 435kcal
Author Sara Welch


  • 2 tablespoons butter
  • 14 ounce bag Birdseye C&W Ultimate Southwest Blend
  • 4 cups cooked, diced chicken
  • 10 ounce can mild enchilada sauce
  • 1 cup sour cream plus more for garnish
  • 8 ounce bag Mexican Style Shredded Cheese
  • 8 flour tortillas soft taco size, cut into squares
  • 3/4 cup tomatoes seeded and diced
  • 2 tablespoons cilantro leaves chopped
  • cooking spray


  • Preheat the oven to 350 degrees F. Coat a 2 or 3 quart casserole dish with cooking spray.
  • Melt the butter in a large pan over medium heat. Add the bag of vegetables and cook for 3-4 minutes or until thawed.
  • Add the chicken to the pan and cook for an additional 2-3 minutes or until warmed through.
  • Place the chicken and vegetables in a large bowl. Add the enchilada sauce, sour cream, and half of the bag of cheese. Stir to combine.
  • Spread 1/3 of the tortilla pieces in the bottom of the dish. Add half of the chicken mixture, then top with another 1/3 of the tortillas.
  • Add the remaining chicken, then top with the rest of the tortillas. Sprinkle the remaining shredded cheese over the top.
  • Cover the dish with foil and bake for 15 minutes. Uncover and bake for an additional 15 minutes or until casserole is bubbly and cheese is melted.
  • Top with tomatoes and cilantro, then serve.


Make Ahead Instructions: Assemble the casserole, then cover with foil and refrigerate for up to 24 hours. Preheat oven to 350 degrees, then bake covered for 30 minutes. Uncover and bake for an additional 15 minutes or until cheese is melted and starting to brown.


Calories: 435kcal | Carbohydrates: 35g | Protein: 29g | Fat: 21g | Saturated Fat: 12g | Cholesterol: 106mg | Sodium: 596mg | Potassium: 428mg | Fiber: 2g | Sugar: 5g | Vitamin A: 940IU | Vitamin C: 7.4mg | Calcium: 327mg | Iron: 2.6mg